- CAS 615-43-0
- Purity 99%
Location：Home > Agrochemicals > 2-Iodoaniline
Cost-effective and customizable 2-Iodoaniline 615-43-0 supplier
- Molecular Formula: C6H6IN
- Molecular Weight: 219.025
- Appearance/Colour: yellow to brown crystalline needles
- Vapor Pressure: 0.0112mmHg at 25°C
- Melting Point: 55-58 °C(lit.)
- Refractive Index: 1.688
- Boiling Point: 262 °C at 760 mmHg
- PKA: 2.6(at 25℃)
- Flash Point: 112.3 °C
- PSA： 26.02000
- Density: 1.924 g/cm3
- LogP: 2.45460
2-Iodoaniline(Cas 615-43-0) Usage
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Preparation |
2-iodoaniline and its derivatives are commonly used for the preparation of indole-based anticancer drugs, which have high market value, and further synthesis can lead to high-end synthetic intermediates with complex structures.Take a reaction tube, add 50mg of sodium azide, 75mg of 1-(2-iodophenyl)ethanol, 300uL of trifluoroacetic acid, 150uL of methanesulfonic acid and 1.0mL of hexane, and stir for 24 hours at 40℃. After the reaction, 10 mL of sodium hydroxide solution was added to quench the reaction. The organic phase was washed with 5 mL of brine, and the organic phase was combined and separated by column chromatography to obtain 58.4 mg of 2-iodoaniline in 89% yield.Synthesis of 2-iodoaniline |
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Purification Methods |
Distil 2-iodoaniline with steam and crystallise it from *benzene/pet ether. The N-acetyl derivative has m 110o. [Beilstein 12 IV 1542.] |
InChI:InChI=1/C6H6IN/c7-5-3-1-2-4-6(5)8/h1-4H,8H2
615-43-0 Relevant articles
Phenotyping Reveals Targets of a Pseudo-Natural-Product Autophagy Inhibitor
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Pseudo-natural-product (NP) design combi...
Efficient and recyclable bimetallic Co–Cu catalysts for selective hydrogenation of halogenated nitroarenes
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615-43-0 Process route
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15111-14-5
2-iodo-N-(phenylmethylene)-benzenamine
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883-93-2
2-Phenylbenzothiazole
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-
615-43-0
2-iodophenylamine
-
-
100-52-7
benzaldehyde
Conditions
| Conditions | Yield |
|---|---|
|
With
1,10-Phenanthroline; copper(II) choride dihydrate; potassium carbonate; sulfur;
In
water;
at 100 ℃;
for 24h;
|
78%
80% 18% |
-
-
79271-23-1
2-iodophenyl hydroxamic acid
-
-
615-43-0
2-iodophenylamine
Conditions
| Conditions | Yield |
|---|---|
|
With
potassium carbonate;
In
dimethyl sulfoxide;
at 90 ℃;
for 2h;
|
98%
|
|
With
potassium carbonate;
In
dimethyl sulfoxide;
at 90 ℃;
for 2h;
|
96%
|
|
2-iodophenyl hydroxamic acid;
With
acetic anhydride; potassium carbonate;
In
dimethyl sulfoxide;
at 50 ℃;
for 2h;
With
hydrogenchloride;
In
water; dimethyl sulfoxide;
at 0 ℃;
|
94%
|
615-43-0 Upstream products
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-
6819-41-6
sodium n-propoxide
615-43-0 Downstream products
-
98041-44-2
2-iodophenyl isothiocyanate
-
117500-16-0
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-
72601-45-7
1-(2-iodophenyl)pyrrolidine-2,5-dione
-
888282-88-0
N -(4-bromo-phenyl)-N '-(2-iodo-phenyl)-urea