- CAS 1465-76-5
- Purity 99%
Location：Home > Others > 1-TERT-BUTYL-PIPERIDIN-4-ONE
Cost-effective and customizable 1-TERT-BUTYL-PIPERIDIN-4-ONE 1465-76-5 factory
- Molecular Formula: C9H17NO
- Molecular Weight: 155.24
- Vapor Pressure: 0.0883mmHg at 25°C
- Melting Point: 92-94 °C (sublm)(Press: 10 Torr)
- Refractive Index: 1.472
- Boiling Point: 225 °C at 760 mmHg
- PKA: 8.26±0.20(Predicted)
- Flash Point: 83.5 °C
- PSA： 20.31000
- Density: 0.968 g/cm3
- LogP: 1.38770
1-TERT-BUTYL-PIPERIDIN-4-ONE(Cas 1465-76-5) Usage
|
General Description |
1-TERT-BUTYL-PIPERIDIN-4-ONE is a key intermediate in the synthesis of pharmaceutical compounds, such as p38 MAP kinase inhibitors, where it serves as a precursor for Grignard reactions. Its efficient preparation via transamination is facilitated by trapping dimethylamine with sodium acrylate, enabling high-yield production and simplified purification. 1-TERT-BUTYL-PIPERIDIN-4-ONE is particularly valuable in large-scale drug synthesis, as demonstrated in the development of therapeutics for rheumatoid arthritis and psoriasis. |
InChI:InChI=1/C9H17NO/c1-9(2,3)10-6-4-8(11)5-7-10/h4-7H2,1-3H3
1465-76-5 Relevant articles
Acrylate as an efficient dimethylamine trap for the practical synthesis of 1-tert-butyl-4-piperidone via transamination
Amato, Joseph S.,Chung, John Y. L.,Cvetovich, Raymond J.,Reamer, Robert A.,Zhao, Dalian,Zhou, George,Gong, Xiaoyi
, p. 939 - 941 (2004)
Efficient trapping of dimethylamine was ...
Synthesis of a naphthyridone p38 MAP kinase inhibitor
Chung, John Y. L.,Cvetovich, Raymond J.,McLaughlin, Mark,Amato, Joseph,Tsay, Fuh-Rong,Jensen, Mark,Weissman, Steve,Zewge, Daniel
, p. 8602 - 8609 (2006)
Compound 1 is a p38 MAP kinase inhibitor...
Fused tricyclic hepatitis virus inhibitor and application thereof
-
Paragraph 0696; 0697; 0698; 0699; 0700, (2016/12/26)
The invention belongs to the field of me...
AZACYCLIC COMPOUNDS
-
Paragraph 0666, (2015/11/09)
Compounds and methods are provided for t...
Spiroalkene carboxamide derivatives and their use as chemokine receptor modulators
-
Page/Page column 53, (2012/10/18)
The present invention is directed to com...
SPIROALKENE CARBOXAMIDE DERIVATIVES AND THEIR USE AS CHEMOKINE RECEPTOR MODULATORS
-
Page/Page column 64, (2012/10/18)
The present invention is directed to com...
1465-76-5 Process route
-
-
77542-18-8
1-methyl-1-ethyl-4-oxopiperidinium iodide
-
-
75-64-9
tert -butylamine
-
-
1465-76-5
1-tert-butyl-piperidin-4-one
Conditions
| Conditions | Yield |
|---|---|
|
With
sodium hydrogencarbonate;
In
water; toluene;
at 0 - 80 ℃;
for 5h;
|
37%
|
|
With
sodium hydrogencarbonate;
In
water; toluene;
at 0 - 80 ℃;
for 5h;
|
37%
|
|
With
sodium hydrogencarbonate;
In
water; toluene;
at 78 ℃;
for 6h;
|
|
|
With
sodium hydrogencarbonate;
In
water; toluene;
at 78 ℃;
for 6h;
|
-
-
26822-37-7
N,N-dimethyl-4-oxopiperidinium iodide
-
-
75-64-9
tert -butylamine
-
-
1465-76-5
1-tert-butyl-piperidin-4-one
Conditions
| Conditions | Yield |
|---|---|
|
With
sodium 2-propenoate;
In
water;
|
87%
|
|
With
sodium hydroxide; acrylic acid;
In
water;
at 65 ℃;
for 3h;
Inert atmosphere;
|
75%
|
|
N,N-dimethyl-4-oxopiperidinium iodide; tert-butylamine;
In
water;
for 0.25h;
With
N-benzyl-trimethylammonium hydroxide;
In
methanol; water;
for 2h;
Heating / reflux;
With
sodium hydroxide;
In
water;
|
|
|
With
acrylic acid; sodium hydroxide;
In
water;
at 80 ℃;
for 3h;
|
1465-76-5 Upstream products
-
1445-73-4
1-Methyl-4-piperidone
-
75-64-9
tert -butylamine
-
26822-37-7
N,N-dimethyl-4-oxopiperidinium iodide
-
77542-18-8
1-methyl-1-ethyl-4-oxopiperidinium iodide
1465-76-5 Downstream products
-
57982-78-2
budipine
-
5382-30-9
1-(1,1-dimethylethyl)-4-piperidinol
-
359880-72-1
4-(4-methylbenzylamino)-1-tert-butylpiperidine
-
844443-82-9
N-benzyl-1-tert-butylpiperidin-4-amine