- CAS 16620-52-3
- Purity 99%
Location：Home > Others > 5-METHOXYGRAMINE
High Quality Chinese Factory supply 16620-52-3 5-METHOXYGRAMINE
- Molecular Formula: C12H16N2O
- Molecular Weight: 204.272
- Appearance/Colour: white to almost white crystalline powder
- Vapor Pressure: 0.000126mmHg at 25°C
- Melting Point: 123-126 °C(lit.)
- Refractive Index: 1.6000 (estimate)
- Boiling Point: 334.677 °C at 760 mmHg
- PKA: 16.70±0.30(Predicted)
- Flash Point: 156.207 °C
- PSA： 28.26000
- Density: 1.12 g/cm3
- LogP: 2.23810
5-METHOXYGRAMINE(Cas 16620-52-3) Usage
InChI:InChI=1/C12H16N2O/c1-14(2)8-9-7-13-12-5-4-10(15-3)6-11(9)12/h4-7,13H,8H2,1-3H3/p+1
16620-52-3 Relevant articles
Catalyst-Controlled Regiodivergence in Rearrangements of Indole-Based Onium Ylides
Nair, Vaishnavi N.,Kojasoy, Volga,Laconsay, Croix J.,Kong, Wang Yeuk,Tantillo, Dean J.,Tambar, Uttam K.
, p. 9016 - 9025 (2021)
We have developed catalyst-controlled re...
Rhodium-Catalyzed Stereoselective Cyclization of 3-Allenylindoles and N-Allenyltryptamines to Functionalized Vinylic Spiroindolenines
Becker, Antonia,Breit, Bernhard,Grugel, Christian P.
supporting information, p. 3788 - 3792 (2021/05/29)
Herein, we report a highly enantio- and ...
Rhodium-Catalyzed Enantioselective Cyclization of 3-Allenyl-indoles: Access to Functionalized Tetrahydrocarbazoles
Grugel, Christian P.,Breit, Bernhard
supporting information, p. 5798 - 5802 (2019/06/08)
A highly selective rhodium-catalyzed cyc...
Rhodium-Catalyzed Diastereo- And Enantioselective Tandem Spirocyclization/Reduction of 3-Allenylindoles: Access to Functionalized Vinylic Spiroindolines
Grugel, Christian P.,Breit, Bernhard
supporting information, p. 9672 - 9676 (2019/12/24)
A highly selective rhodium-catalyzed tan...
16620-52-3 Process route
-
-
1006-94-6
5-methoxylindole
-
-
50-00-0,30525-89-4,61233-19-0
formaldehyd
-
-
124-40-3
dimethyl amine
-
-
16620-52-3
5-methoxygramine
Conditions
| Conditions | Yield |
|---|---|
|
|
78%
|
|
With
acetic acid;
In
water;
at 10 - 30 ℃;
|
75.2%
|
|
formaldehyd; dimethyl amine;
With
acetic acid;
In
tetrahydrofuran; water;
at 0 ℃;
for 0.166667h;
5-methoxylindole;
In
tetrahydrofuran; water;
at 20 ℃;
|
56%
|
|
With
acetic acid;
|
|
|
With
acetic acid;
In
tetrahydrofuran; 1,4-dioxane; water;
at 0 - 20 ℃;
|
|
|
formaldehyd; dimethyl amine;
With
acetic acid;
In
tetrahydrofuran; 1,4-dioxane; water;
at 0 ℃;
for 0.0833333h;
Schlenk technique;
Inert atmosphere;
5-methoxylindole;
In
tetrahydrofuran; 1,4-dioxane; water;
at 0 - 20 ℃;
Schlenk technique;
Inert atmosphere;
|
|
|
formaldehyd; dimethyl amine;
With
acetic acid;
In
1,4-dioxane; water;
at 0 ℃;
for 0.25h;
Inert atmosphere;
Schlenk technique;
5-methoxylindole;
In
1,4-dioxane; water;
at 0 - 20 ℃;
for 18h;
Inert atmosphere;
Schlenk technique;
|
|
|
In
water; acetic acid;
at 0 - 23 ℃;
for 16.25h;
|
-
-
1006-94-6
5-methoxylindole
-
-
16620-52-3
5-methoxygramine
Conditions
| Conditions | Yield |
|---|---|
|
With
formaldehyd; dimethyl amine;
In
1,4-dioxane; acetic acid;
|
16620-52-3 Upstream products
-
10467-10-4
ethylmagnesium iodide
-
1006-94-6
5-methoxylindole
-
60-29-7
diethyl ether
-
926-64-7
N,N-Dimethylamino acetonitrile
16620-52-3 Downstream products
-
54744-69-3
acetylamino-(5-methoxy-indol-3-ylmethyl)-malonic acid diethyl ester
-
2436-17-1
5-methoxyindole-3-acetonitrile
-
113997-50-5
1-(5-methoxyindol-3-yl)-2-nitropropane
-
947767-33-1
C26 H27 N3 O3