1-Phenylcyclobutanecarbonitrile


  • CAS 14377-68-5
  • Purity 99%
Inquiry

High Quality Chinese Manufacturer supply 14377-68-5 1-Phenylcyclobutanecarbonitrile

  • Molecular Formula: C11H11N
  • Molecular Weight: 157.215
  • Appearance/Colour: clear light yellow liquid 
  • Vapor Pressure: 0.00201mmHg at 25°C 
  • Refractive Index: 1.5313-1.5333  
  • Boiling Point: 290.9 °C at 760 mmHg 
  • Flash Point: 106.3 °C 
  • PSA: 23.79000 
  • Density: 1.06 g/cm3 
  • LogP: 2.63188 

1-Phenylcyclobutanecarbonitrile(Cas 14377-68-5) Usage

InChI:InChI=1/C11H11N/c12-9-11(7-4-8-11)10-5-2-1-3-6-10/h1-3,5-6H,4,7-8H2

14377-68-5 Relevant articles

Phase transfer alkylation of arylacetonitriles revisited

Barbasiewicz, Micha?,Marciniak, Karolina,Fedoryński, Micha?

, p. 3871 - 3874 (2006)

Phase transfer alkylations of phenylacet...

Amide compound and derivative thereof, preparation method, pharmaceutical composition and application thereof

-

Paragraph 0390-0393, (2021/07/09)

The invention discloses an amide compoun...

Iridium-Catalyzed Enantioselective C(sp3)–H Borylation of Cyclobutanes

Chen, Xiang,Chen, Lili,Zhao, Hongliang,Gao, Qian,Shen, Zhenlu,Xu, Senmiao

supporting information, p. 1533 - 1537 (2020/09/09)

We herein report the first example of ir...

HETEROCYCLIC COMPOUND

-

Paragraph 0664, (2016/09/26)

The problem of the present invention is ...

Identification of A Novel Small-Molecule Binding Site of the Fat Mass and Obesity Associated Protein (FTO)

He, Wu,Zhou, Bin,Liu, Weijia,Zhang, Meizi,Shen, Zhenhua,Han, Zhifu,Jiang, Qingwei,Yang, Qinghua,Song, Chuanjun,Wang, Ruiyong,Niu, Tianhui,Han, Shengna,Zhang, Lirong,Wu, Jie,Guo, Feima,Zhao, Renbin,Yu, Wenquan,Chai, Jijie,Chang, Junbiao

, p. 7341 - 7348 (2015/10/05)

N-(5-Chloro-2,4-dihydroxyphenyl)-1-pheny...

14377-68-5 Process route

phenylacetonitrile
140-29-4

phenylacetonitrile

1-phenylcyclobutanecarbonitrile
14377-68-5

1-phenylcyclobutanecarbonitrile

Conditions
Conditions Yield
With ammonia; sodium amide; anschliessend mit 1.3-Dibrom-propan in Aether bei -50grad und Erwaermen des mit Aether oder Toluol versetzten Reaktionsgemisches;
With di-isopropyl ether; sodium amide; Behandeln des gekuehlten Reaktionsgemisches mit 1.3-Dibrompropan in Diisopropylaether bzw. in Toluol und anschliessend Erhitzen auf Siedetemperatur;
With sodium amide; toluene; Behandeln des gekuehlten Reaktionsgemisches mit 1.3-Dibrompropan in Diisopropylaether bzw. in Toluol und anschliessend Erhitzen auf Siedetemperatur;
phenylacetonitrile
140-29-4

phenylacetonitrile

1,3-Dichloropropane
142-28-9

1,3-Dichloropropane

1-phenylcyclobutanecarbonitrile
14377-68-5

1-phenylcyclobutanecarbonitrile

Conditions
Conditions Yield
Multistep reaction; (i) nBuLi, (ii) /BRN= 505960/;

14377-68-5 Upstream products

  • 140-29-4
    140-29-4

    phenylacetonitrile

  • 109-64-8
    109-64-8

    1,3-dibromo-propane

  • 142-28-9
    142-28-9

    1,3-Dichloropropane

14377-68-5 Downstream products

  • 3972-67-6
    3972-67-6

    1-(1-phenylcyclobutyl)ethan-1-one

  • 4620-67-1
    4620-67-1

    1-phenylcyclobutane-carbonyl chloride

  • 37828-19-6
    37828-19-6

    1-(phenyl)cyclobutane-1-carboxylic acid

  • 91245-59-9
    91245-59-9

    (1-phenylcyclobutyl)-methanamine

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