- CAS 6164-79-0
- Purity 99%
Location：Home > Pharmaceutical > METHYL PYRAZINE-2-CARBOXYLATE
METHYL PYRAZINE-2-CARBOXYLATE GMP Manufacturer Global Trade 6164-79-0 with Fast Delivery
- Molecular Formula: C6H6N2O2
- Molecular Weight: 138.126
- Appearance/Colour: white powder
- Vapor Pressure: 0.113mmHg at 25°C
- Melting Point: 57-61 °C(lit.)
- Refractive Index: 1.513
- Boiling Point: 220.4 °C at 760 mmHg
- PKA: -0.91±0.10(Predicted)
- Flash Point: 87.1 °C
- PSA： 52.08000
- Density: 1.213 g/cm3
- LogP: 0.26320
METHYL PYRAZINE-2-CARBOXYLATE(Cas 6164-79-0) Usage
InChI:InChI=1/C6H6N2O2/c1-10-6(9)5-4-7-2-3-8-5/h2-4H,1H3
6164-79-0 Relevant articles
Design, synthesis and antibacterial activities of 5-(pyrazin-2-yl)-4H-1,2, 4-triazole-3-thiol derivatives containing Schiff base formation as FabH inhibitory
Zhang, Fei,Wen, Qing,Wang, She-Feng,Shahla Karim, Baloch,Yang, Yu-Shun,Liu, Jia-Jia,Zhang, Wei-Ming,Zhu, Hai-Liang
, p. 90 - 95 (2014)
A series of novel schiff base derivative...
Design, synthesis, anti-mycobacterial and cytotoxic evaluation of C-4 functionalized 1,8-naphthalimide-heterocyclic hydrazide conjugates
Shalini,Johansen, Matt D.,Kremer, Laurent,Kumar, Vipan
, p. 1300 - 1305 (2019)
This manuscript discloses the design and...
Cobalt and silver complexes of terdentate pyrazine-based amide ligands and assembly of monocobalt building blocks through a silver connector
Hellyer, Ryan M.,Larsen, David S.,Brooker, Sally
, p. 1162 - 1171 (2009)
Two terdentate pyrazine-based amide liga...
Evaluation and Docking Study of Pyrazine Containing 1, 3, 4-Oxadiazoles Clubbed with Substituted Azetidin-2-one: A New Class of Potential Antimicrobial and Antitubercular
Das, Rina,Mehta, Dinesh Kumar
, p. 26 - 35 (2021)
Background Tuberculosis (TB) caused by M...
-
Marx,Spoerri
, p. 111 (1972)
-
A chromone hydrazide Schiff base fluorescence probe with high selectivity and sensitivity for the detection and discrimination of human serum albumin (HSA) and bovine serum albumin (BSA)
Fan, Jing,Li, Qing-Zhong,Li, Zhe,Liu, Hai-Bo,Wang, Zhi-Gang,Xie, Cheng-Zhi,Xu, Jing-Yuan,Yan, Xiao-Jing
, (2021/10/12)
The discrimination and identification of...
New silver(I) phosphino complexes: Evaluation of their potential as prospective agents against Mycobacterium tuberculosis
Gambino, Dinorah,Maldonado, Yndira Dolores,Manieri, Karyn Fernanda,Pavan, Fernando R.,Scalese, Gonzalo,Aguirre Méndez, Larry D.
, (2021/12/14)
Despite being a preventable and curable ...
PIEZO1 AGONISTS FOR THE PROMOTION OF BONE FORMATION
-
Page/Page column 30; 32, (2021/04/10)
Disclosed herein are Piezo 1 agonists. A...
1H-1,2,3-triazole embedded Isatin-Benzaldehyde-bis(heteronuclearhydrazones): design, synthesis, antimycobacterial, and cytotoxic evaluation
Johansen, Matt D.,Kremer, Laurent,Kumar, Sumit,Kumar, Vipan,Preeti,Sharma, Bharvi
, (2021/12/09)
Rapid growth of global drug-resistant tu...
6164-79-0 Process route
-
-
6164-79-0
methyl pyrazine-2-carboxylate
-
-
5780-66-5
pyrazinecarboxaldehyde
Conditions
| Conditions | Yield |
|---|---|
|
|
84%
|
|
|
84%
|
-
-
67-56-1
methanol
-
-
98-97-5
2-pyrazylcarboxylic acid
-
-
6164-79-0
methyl pyrazine-2-carboxylate
Conditions
| Conditions | Yield |
|---|---|
|
With
sulfuric acid;
for 2h;
Reflux;
|
98%
|
|
With
sulfuric acid;
for 48h;
Heating;
|
95%
|
|
With
sulfuric acid;
at 80 - 85 ℃;
for 5h;
|
94.8%
|
|
With
sulfuric acid;
at 20 ℃;
for 72h;
|
93%
|
|
With
sulfuric acid;
at 55 - 65 ℃;
for 19h;
Temperature;
Industrial scale;
|
91%
|
|
With
dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
methanol;
at 0 - 20 ℃;
|
90%
|
|
methanol; 2-pyrazylcarboxylic acid;
With
thionyl chloride;
for 60h;
With
potassium carbonate;
In
dichloromethane;
for 1h;
|
89%
|
|
methanol;
With
thionyl chloride;
at -10 ℃;
for 0.5h;
Inert atmosphere;
2-pyrazylcarboxylic acid;
In
methanol;
at 20 ℃;
for 72h;
With
sodium hydrogencarbonate;
In
water;
|
87%
|
|
With
sulfuric acid;
for 3h;
Reflux;
|
86%
|
|
With
chloro-trimethyl-silane;
at 65 ℃;
for 1h;
|
82%
|
|
With
thionyl chloride;
at 0 - 20 ℃;
|
80%
|
|
With
thionyl chloride;
at 20 ℃;
for 1h;
|
80%
|
|
With
sulfuric acid;
for 6h;
Reflux;
|
72%
|
|
With
thionyl chloride;
at 60 ℃;
for 2h;
|
66%
|
|
With
sulfuric acid;
for 5h;
Reflux;
|
63.63%
|
|
2-pyrazylcarboxylic acid;
With
oxalyl dichloride; N,N-dimethyl-formamide;
In
dichloromethane;
at 23 ℃;
for 6h;
methanol;
for 0.5h;
|
53%
|
|
With
sulfuric acid;
|
|
|
With
hydrogenchloride;
|
|
|
With
sulfuric acid;
for 6h;
Reflux;
|
|
|
With
sulfuric acid;
In
methanol;
for 6h;
Heating / reflux;
|
|
|
With
sulfuric acid;
|
|
|
Acidic conditions;
|
|
|
2-pyrazylcarboxylic acid;
With
chloroformic acid ethyl ester; triethylamine;
In
chloroform;
at -10 ℃;
Inert atmosphere;
methanol;
In
chloroform;
at 20 ℃;
|
|
|
With
thionyl chloride;
for 72h;
Reflux;
|
|
|
With
sulfuric acid;
Reflux;
|
|
|
With
thionyl chloride;
at 0 - 20 ℃;
for 1h;
|
|
|
With
sulfuric acid;
for 12h;
Reflux;
|
|
|
With
sulfuric acid;
Inert atmosphere;
|
|
|
With
sulfuric acid;
at 65 - 67 ℃;
for 4h;
|
|
|
With
sulfuric acid;
for 10h;
Reflux;
|
|
|
With
sulfuric acid;
for 5h;
Reflux;
|
|
|
With
sulfuric acid;
for 5h;
Reflux;
|
|
|
for 7h;
Reflux;
|
|
|
With
sulfuric acid;
at 85 - 95 ℃;
for 2h;
|
|
|
With
thionyl chloride;
|
6164-79-0 Upstream products
-
67-56-1
methanol
-
98-97-5
2-pyrazylcarboxylic acid
-
73763-86-7
3-[(methyloxy)carbonyl]-2-pyrazinecarboxylic acid
-
290-37-9
1,4-pyrazine
6164-79-0 Downstream products
-
100885-36-7
pyrazine-2-carboxylic acid-[(1R ,2R )-2-hydroxy-1-hydroxymethyl-2-(4-nitro-phenyl)-ethylamide]
-
62124-77-0
3-oxo-3-pyrazin-2-yl-propionic acid ethyl ester
-
75908-56-4
pyrazine-2-carboxylic acid-(4-methoxy-benzylamide)
-
80364-57-4
pyrazine-2-carboxylic acid N'-methylhydrazide